PDBe 2j4a

X-ray diffraction
2.2Å resolution

Human Thyroid hormone receptor beta ligand binding domain in complex with KB131084

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Thyroid hormone receptor beta Chain: A
Molecule details ›
Chain: A
Length: 253 amino acids
Theoretical weight: 28.56 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P10828 (Residues: 209-461; Coverage: 55%)
Gene names: ERBA2, NR1A2, THR1, THRB
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: EMBL/DESY, HAMBURG BEAMLINE BW7A
Spacegroup: C2221
Unit cell:
a: 77.212Å b: 107.422Å c: 67.208Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.23 0.23 0.273
Expression system: Escherichia coli