EC 3.4.22.56: Caspase-3
Reaction catalysed:
Strict requirement for an Asp residue at positions P1 and P4. It has a preferred cleavage sequence of Asp-Xaa-Xaa-Asp-|- with a hydrophobic amino-acid residue at P2 and a hydrophilic amino-acid residue at P3, although Val or Ala are also accepted at this position
Systematic name:
-
Alternative Name(s):
- Apopain
- CASP-3
- CPP32
- Yama protein
GO terms
Biochemical function:
- cysteine-type endopeptidase activity involved in execution phase of apoptosis
- cysteine-type endopeptidase activity involved in apoptotic signaling pathway
- cysteine-type endopeptidase activity involved in apoptotic process
- protein-containing complex binding
- hydrolase activity
- phospholipase A2 activator activity
- cysteine-type peptidase activity
- peptidase activity
- enzyme activator activity
- protein binding
- death receptor binding
- cyclin-dependent protein serine/threonine kinase inhibitor activity
- cysteine-type endopeptidase activity
- aspartic-type endopeptidase activity
- endopeptidase activity
- protease binding
Biological process:
- epithelial cell apoptotic process
- positive regulation of amyloid-beta formation
- positive regulation of pyroptosis
- execution phase of apoptosis
- intrinsic apoptotic signaling pathway
- apoptotic signaling pathway
- cellular response to staurosporine
- leukocyte apoptotic process
- cellular response to organic cyclic compound
- cellular response to organic substance
- pyroptosis
- anterior neural tube closure
- cellular response to stimulus
- protein maturation
- neuron apoptotic process
- response to glucocorticoid
- striated muscle cell differentiation
- neurotrophin TRK receptor signaling pathway
- negative regulation of activated T cell proliferation
- negative regulation of cell cycle
- cell fate commitment
- fibroblast apoptotic process
- positive regulation of neuron apoptotic process
- response to amino acid
- positive regulation of apoptotic process
- T cell homeostasis
- response to hydrogen peroxide
- intracellular signal transduction
- response to nicotine
- response to tumor necrosis factor
- glial cell apoptotic process
- response to lipopolysaccharide
- response to estradiol
- response to cobalt ion
- regulation of protein stability
- negative regulation of B cell proliferation
- platelet formation
- erythrocyte differentiation
- keratinocyte differentiation
- neuron differentiation
- protein catabolic process
- hippocampus development
- protein processing
- regulation of macroautophagy
- response to organic cyclic compound
- response to X-ray
- response to metal ion
- response to organic substance
- response to glucose
- response to wounding
- response to UV
- response to xenobiotic stimulus
- intrinsic apoptotic signaling pathway in response to osmotic stress
- learning or memory
- sensory perception of sound
- heart development
- axonal fasciculation
- DNA damage response
- apoptotic process
- proteolysis
- negative regulation of cytokine production
- B cell homeostasis
- response to hypoxia
- luteolysis
Protein family (Pfam)
InterPro annotations
CATH domain