PDBe 2j2i

X-ray diffraction
1.9Å resolution

Crystal Structure of the humab PIM1 in complex with LY333531

Released:
Source organism: Homo sapiens

Function and Biology Details

Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein. 
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Serine/threonine-protein kinase pim-1 Chain: B
Molecule details ›
Chain: B
Length: 312 amino acids
Theoretical weight: 35.5 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P11309 (Residues: 92-403; Coverage: 77%)
Gene name: PIM1
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU FRE
Spacegroup: P65
Unit cell:
a: 98.157Å b: 98.157Å c: 80.366Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.18 0.179 0.2
Expression system: Escherichia coli