PDBe 2j0l

X-ray diffraction
2.3Å resolution

Crystal structure of a the active conformation of the kinase domain of focal adhesion kinase with a phosphorylated activation loop.

Source organism: Gallus gallus

Function and Biology Details

Reaction catalysed:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. 
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Focal adhesion kinase 1 Chain: A
Molecule details ›
Chain: A
Length: 276 amino acids
Theoretical weight: 31.92 KDa
Source organism: Gallus gallus
Expression system: Trichoplusia ni
  • Canonical: Q00944 (Residues: 411-686; Coverage: 26%)
Gene names: FAK, FAK1, PTK2
Sequence domains: Protein tyrosine kinase
Structure domains:

Ligands and Environments

3 bound ligands:

1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X29A
Spacegroup: P212121
Unit cell:
a: 44.312Å b: 71.809Å c: 86.939Å
α: 90° β: 90° γ: 90°
R R work R free
0.217 0.214 0.263
Expression system: Trichoplusia ni