PDBe 2j0i

X-ray diffraction
1.6Å resolution

CRYSTAL STRUCTURE OF THE HUMAN P21-ACTIVATED KINASE 4

Released:
Source organism: Homo sapiens
Entry authors: Debreczeni JE, Eswaran J, Ugochukwu E, Papagrigoriou E, Turnbull A, Von Delft F, Arrowsmith C, Weigelt J, Edwards A, Sundstrom M, Knapp S

Function and Biology Details

Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein. 
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Serine/threonine-protein kinase PAK 4 Chain: A
Molecule details ›
Chain: A
Length: 303 amino acids
Theoretical weight: 34.24 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O96013 (Residues: 291-591; Coverage: 51%)
Gene names: KIAA1142, PAK4
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

1 bound ligand:

1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: P41212
Unit cell:
a: 63.514Å b: 63.514Å c: 178.478Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.174 0.172 0.215
Expression system: Escherichia coli