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CRYSTAL STRUCTURE OF SOCS-4 IN COMPLEX WITH ELONGIN-B AND ELONGIN-C AT 2.55A RESOLUTION

Source organism: Homo sapiens
Biochemical function: ubiquitin protein ligase binding
Biological process: ubiquitin-dependent protein catabolic process
Cellular component: elongin complex

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GO terms

Sequence families

Pfam Protein families (Pfam)
PF03931
Domain description: Skp1 family, tetramerisation domain
Occurring in:
  1. Elongin-C
The deposited structure of PDB entry 2izv contains 1 copy of Pfam domain PF03931 (Skp1 family, tetramerisation domain) in Elongin-C. Showing 1 copy in chain C.

PF00240
Domain description: Ubiquitin family
Occurring in:
  1. Elongin-B
The deposited structure of PDB entry 2izv contains 1 copy of Pfam domain PF00240 (Ubiquitin family) in Elongin-B. Showing 1 copy in chain B.

PF07525
Domain description: SOCS box
Occurring in:
  1. Suppressor of cytokine signaling 4
The deposited structure of PDB entry 2izv contains 1 copy of Pfam domain PF07525 (SOCS box) in Suppressor of cytokine signaling 4. Showing 1 copy in chain A.

PF00017
Domain description: SH2 domain
Occurring in:
  1. Suppressor of cytokine signaling 4
The deposited structure of PDB entry 2izv contains 1 copy of Pfam domain PF00017 (SH2 domain) in Suppressor of cytokine signaling 4. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR001496
Domain description: SOCS box domain
Occurring in:
  1. Suppressor of cytokine signaling 4
IPR000626
Domain description: Ubiquitin-like domain
Occurring in:
  1. Elongin-B
IPR000980
Domain description: SH2 domain
Occurring in:
  1. Suppressor of cytokine signaling 4
IPR011333
Domain description: SKP1/BTB/POZ domain superfamily
Occurring in:
  1. Elongin-C
IPR036860
Domain description: SH2 domain superfamily
Occurring in:
  1. Suppressor of cytokine signaling 4
IPR016073
Domain description: SKP1 component, POZ domain
Occurring in:
  1. Elongin-C
IPR039948
Domain description: Elongin-C
Occurring in:
  1. Elongin-C
IPR001232
Domain description: S-phase kinase-associated protein 1-like
Occurring in:
  1. Elongin-C
IPR039049
Domain description: Elongin B
Occurring in:
  1. Elongin-B
IPR029071
Domain description: Ubiquitin-like domain superfamily
Occurring in:
  1. Elongin-B
IPR036036
Domain description: SOCS box-like domain superfamily
Occurring in:
  1. Suppressor of cytokine signaling 4
IPR035864
Domain description: SOCS4, SH2 domain
Occurring in:
  1. Suppressor of cytokine signaling 4

Structure domains

CATH CATH domains
3.30.710.10
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Potassium Channel Kv1.1; Chain A
Homology: Potassium Channel Kv1.1; Chain A
Occurring in:
  1. Elongin-C
The deposited structure of PDB entry 2izv contains 1 copy of CATH domain 3.30.710.10 (Potassium Channel Kv1.1; Chain A) in Elongin-C. Showing 1 copy in chain C.
3.10.20.90
Class: Alpha Beta
Architecture: Roll
Topology: Ubiquitin-like (UB roll)
Homology: Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 1
Occurring in:
  1. Elongin-B
The deposited structure of PDB entry 2izv contains 1 copy of CATH domain 3.10.20.90 (Ubiquitin-like (UB roll)) in Elongin-B. Showing 1 copy in chain B.
3.30.505.10
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: SHC Adaptor Protein
Homology: SH2 domain
Occurring in:
  1. Suppressor of cytokine signaling 4
The deposited structure of PDB entry 2izv contains 1 copy of CATH domain 3.30.505.10 (SHC Adaptor Protein) in Suppressor of cytokine signaling 4. Showing 1 copy in chain A.
SCOP SCOP annotations
54696
Class: Alpha and beta proteins (a+b)
Fold: POZ domain
Superfamily: POZ domain
Occurring in:
  1. Elongin-C
The deposited structure of PDB entry 2izv contains 1 copy of SCOP domain 54696 (BTB/POZ domain) in Elongin-C. Showing 1 copy in chain C.
54237
Class: Alpha and beta proteins (a+b)
Fold: beta-Grasp (ubiquitin-like)
Superfamily: Ubiquitin-like
Occurring in:
  1. Elongin-B
The deposited structure of PDB entry 2izv contains 1 copy of SCOP domain 54237 (Ubiquitin-related) in Elongin-B. Showing 1 copy in chain B.
158236
Class: All alpha proteins
Fold: SOCS box-like
Superfamily: SOCS box-like
Occurring in:
  1. Suppressor of cytokine signaling 4
The deposited structure of PDB entry 2izv contains 1 copy of SCOP domain 158236 (SOCS box-like) in Suppressor of cytokine signaling 4. Showing 1 copy in chain A.
55551
Class: Alpha and beta proteins (a+b)
Fold: SH2-like
Superfamily: SH2 domain
Occurring in:
  1. Suppressor of cytokine signaling 4
The deposited structure of PDB entry 2izv contains 1 copy of SCOP domain 55551 (SH2 domain) in Suppressor of cytokine signaling 4. Showing 1 copy in chain A.

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