PDBe 2izr

X-ray diffraction
1.3Å resolution

Structure of casein kinase gamma 3 in complex with inhibitor

Released:
Source organism: Homo sapiens
Entry authors: Bunkoczi G, Salah E, Rellos P, Das S, Fedorov O, Savitsky P, Debreczeni JE, Gileadi O, Sundstrom M, Edwards A, Arrowsmith C, Weigelt J, Von Delft F, Knapp S

Function and Biology Details

Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein. 
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Casein kinase I isoform gamma-3 Chain: A
Molecule details ›
Chain: A
Length: 330 amino acids
Theoretical weight: 38.56 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: Q9Y6M4 (Residues: 33-362; Coverage: 74%)
  • Best match: Q9Y6M4-5 (Residues: 1-287)
Gene name: CSNK1G3
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments


No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: P3121
Unit cell:
a: 56.724Å b: 56.724Å c: 223.344Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.132 0.13 0.158
Expression system: Escherichia coli BL21