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Shikimate kinase from Mycobacterium tuberculosis in complex with shikimate-3-phosphate and ADP

X-ray diffraction
2.3Å resolution
PDB entry 2iyz coloured by chain, front view.
PDB entry 2iyz coloured by chain, side view.
PDB entry 2iyz coloured by chain, top view.
Source organism: Mycobacterium tuberculosis H37Rv
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Shikimate kinase
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Multimeric state: monomeric
Accessible surface area: 8093.98 Å2
Buried surface area: 1168.17 Å2
Dissociation area: 268.59 Å2
Dissociation energy (ΔGdiss): -2.39 kcal/mol
Dissociation entropy (TΔSdiss): 3.53 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-162025

Macromolecules

Shikimate kinase
Chain: A
Length: 184 amino acids
Theoretical weight: 19.68 KDa
Source organism: Mycobacterium tuberculosis H37Rv
Expression system: Escherichia coli
UniProt:
  • Canonical: P9WPY3 (Residues: 1-176; Coverage: 100%)
Gene names: MTCY159.17, Rv2539c, aroK
Pfam: Shikimate kinase
InterPro:
CATH: P-loop containing nucleotide triphosphate hydrolases
SCOP: Shikimate kinase (AroK)
Shikimate kinase in PDB entry 2iyz, assembly 1, front view.
Shikimate kinase in PDB entry 2iyz, assembly 1, side view.
Shikimate kinase in PDB entry 2iyz, assembly 1, top view.
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