PDBe 2iug

X-ray diffraction
1.89Å resolution

Crystal structure of the PI3-kinase p85 N-terminal SH2 domain

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Phosphatidylinositol 3-kinase regulatory subunit alpha Chain: A
Molecule details ›
Chain: A
Length: 120 amino acids
Theoretical weight: 13.94 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P27986 (Residues: 321-440; Coverage: 17%)
  • Best match: P27986-5 (Residues: 1-77)
Gene names: GRB1, PIK3R1
Sequence domains: SH2 domain
Structure domains: SHC Adaptor Protein

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: P41212
Unit cell:
a: 57.12Å b: 57.12Å c: 112.1Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.192 0.192 0.289
Expression system: Escherichia coli BL21(DE3)