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Crystal structure of EGFR kinase domain L858R mutation in complex with AMP-PNP

X-ray diffraction
2.47Å resolution
PDB entry 2itv coloured by chain, front view.
PDB entry 2itv coloured by chain, side view.
PDB entry 2itv coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Epidermal growth factor receptor
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Multimeric state: monomeric
Accessible surface area: 15096.24 Å2
Buried surface area: 763.46 Å2
Dissociation area: 381.73 Å2
Dissociation energy (ΔGdiss): -2.07 kcal/mol
Dissociation entropy (TΔSdiss): 5.27 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-132671

Macromolecules

Epidermal growth factor receptor
Chain: A
Length: 327 amino acids
Theoretical weight: 37.35 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P00533 (Residues: 696-1022; Coverage: 28%)
Gene names: EGFR, ERBB, ERBB1, HER1
Pfam: Protein tyrosine and serine/threonine kinase
InterPro:
CATH:
Epidermal growth factor receptor in PDB entry 2itv, assembly 1, front view.
Epidermal growth factor receptor in PDB entry 2itv, assembly 1, side view.
Epidermal growth factor receptor in PDB entry 2itv, assembly 1, top view.
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