Structure analysis

Crystal Structure of the MHC Class II Molecule HLA-DR1 in Complex with the Fluorogenic Peptide, AcPKXVKQNTLKLAT (X=3-[5-(dimethylamino)-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl]-L-alanine) and the Superantigen, SEC3 Variant 3B2

X-ray diffraction
2.3Å resolution
Assembly composition:
hetero tetramer (preferred)
Entry contents: 4 distinct polypeptide molecules

Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero tetramer
Accessible surface area: 28300 Å2
Buried surface area: 9200 Å2
Dissociation area: 700 Å2
Dissociation energy (ΔGdiss): -3 kcal/mol
Dissociation entropy (TΔSdiss): 13 kcal/mol
Interface energy (ΔGint): -44 kcal/mol
Symmetry number: 1

Macromolecules

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Chain: C
Length: 14 amino acids
Theoretical weight: 1.63 KDa
Source organism: Influenza A virus
Expression system: Not provided
UniProt:
  • Canonical: A8CDU0 (Residues: 59-71; Coverage: 13%)

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