PDBe 2ig7

X-ray diffraction
1.8Å resolution

Crystal structure of Human Choline Kinase B

Source organism: Homo sapiens
Entry authors: Rabeh WM, Tempel W, Nedyalkova L, Wasney G, Landry R, Vedadi M, Arrowsmith CH, Edwards AM, Sundstrom M, Weigelt J, Bochkarev A, Park H, Structural Genomics Consortium (SGC)

Function and Biology Details

Reactions catalysed:
ATP + choline = ADP + phosphocholine. 
ATP + ethanolamine = ADP + O-phosphoethanolamine. 
Biochemical function:
Cellular component:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Choline/ethanolamine kinase Chains: A, B
Molecule details ›
Chains: A, B
Length: 401 amino acids
Theoretical weight: 46.78 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
  • Canonical: Q9Y259 (Residues: 14-395; Coverage: 97%)
Gene names: CHETK, CHKB, CHKL
Sequence domains: Choline/ethanolamine kinase
Structure domains:

Ligands and Environments

1 bound ligand:

1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: P212121
Unit cell:
a: 52.657Å b: 109.208Å c: 157.952Å
α: 90° β: 90° γ: 90°
R R work R free
0.193 0.192 0.227
Expression system: Escherichia coli