PDBe 2ifg

X-ray diffraction
3.4Å resolution

Structure of the extracellular segment of human TRKA in complex with nerve growth factor

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Beta-nerve growth factor Chains: E, F
Molecule details ›
Chains: E, F
Length: 120 amino acids
Theoretical weight: 13.52 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P01138 (Residues: 122-241; Coverage: 54%)
Gene names: NGF, NGFB
Sequence domains: Nerve growth factor family
Structure domains: Cystine-knot cytokines
High affinity nerve growth factor receptor Chains: A, B
Molecule details ›
Chains: A, B
Length: 347 amino acids
Theoretical weight: 37.9 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P04629 (Residues: 36-382; Coverage: 45%)
Gene names: MTC, NTRK1, TRK, TRKA
Sequence domains: Tyrosine-protein kinase receptor C2 Ig-like domain
Structure domains:

Ligands and Environments


No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL11-1
Spacegroup: P21
Unit cell:
a: 110.215Å b: 81.681Å c: 115.748Å
α: 90° β: 104.15° γ: 90°
R-values:
R R work R free
0.297 0.297 0.331
Expression system: Spodoptera frugiperda