2icw Citations

Crystal structure of a complete ternary complex of TCR, superantigen and peptide-MHC.

Nat. Struct. Mol. Biol. 14 169-71 (2007)
Cited: 19 times
EuropePMC logo PMID: 17220897


'Superantigens' (SAgs) trigger the massive activation of T cells by simultaneous interactions with MHC and TCR receptors, leading to human diseases. Here we present the first crystal structure, at 2.5-A resolution, of a complete ternary complex between a SAg and its two receptors, HLA-DR1/HA and TCR. The most striking finding is that the SAg Mycoplasma arthritidis mitogen, unlike others, has direct contacts not only with TCR Vbeta but with TCR Valpha.

Articles - 2icw mentioned but not cited (2)

Reviews citing this publication (5)

  1. Cell death and thymic tolerance. Daley SR, Teh C, Hu DY, Strasser A, Strasser A, Gray DHD. Immunol. Rev. 277 9-20 (2017)
  2. Computational Resources for MHC Ligand Identification. Koch CP, Pillong M, Hiss JA, Schneider G. Mol Inform 32 326-336 (2013)
  3. T cells and their eons-old obsession with MHC. Yin L, Scott-Browne J, Kappler JW, Gapin L, Marrack P. Immunol. Rev. 250 49-60 (2012)
  4. Breaking the wall: targeting of the endothelium by pathogenic bacteria. Lemichez E, Lecuit M, Nassif X, Bourdoulous S. Nat. Rev. Microbiol. 8 93-104 (2010)
  5. Display, engineering, and applications of antigen-specific T cell receptors. Richman SA, Kranz DM. Biomol. Eng. 24 361-373 (2007)

Articles citing this publication (12)

  1. Staphylococcal superantigens cause lethal pulmonary disease in rabbits. Strandberg KL, Rotschafer JH, Vetter SM, Buonpane RA, Kranz DM, Schlievert PM. J. Infect. Dis. 202 1690-1697 (2010)
  2. A bony fish immunological receptor of the NITR multigene family mediates allogeneic recognition. Cannon JP, Haire RN, Magis AT, Eason DD, Winfrey KN, Hernandez Prada JA, Bailey KM, Jakoncic J, Litman GW, Ostrov DA. Immunity 29 228-237 (2008)
  3. Structural features of T cell receptor variable regions that enhance domain stability and enable expression as single-chain ValphaVbeta fragments. Richman SA, Aggen DH, Dossett ML, Donermeyer DL, Allen PM, Greenberg PD, Kranz DM. Mol. Immunol. 46 902-916 (2009)
  4. The structure of superantigen complexed with TCR and MHC reveals novel insights into superantigenic T cell activation. Saline M, Rödström KE, Fischer G, Orekhov VY, Karlsson BG, Lindkvist-Petersson K. Nat Commun 1 119 (2010)
  5. T-cell receptor (TCR) interaction with peptides that mimic nickel offers insight into nickel contact allergy. Yin L, Crawford F, Marrack P, Kappler JW, Dai S. Proc. Natl. Acad. Sci. U.S.A. 109 18517-18522 (2012)
  6. The T cell receptor beta-chain second complementarity determining region loop (CDR2beta governs T cell activation and Vbeta specificity by bacterial superantigens. Nur-ur Rahman AK, Bonsor DA, Herfst CA, Pollard F, Peirce M, Wyatt AW, Kasper KJ, Madrenas J, Sundberg EJ, McCormick JK. J. Biol. Chem. 286 4871-4881 (2011)
  7. Crucial cytokine interactions in nitric oxide production induced by Mycoplasma arthritidis superantigen. Shio MT, Olivier M, Jancar S, Ribeiro-Dias F. Microbes Infect. 10 1543-1551 (2008)
  8. Uptake and intracellular trafficking of superantigens in dendritic cells. Ganem MB, De Marzi MC, Fernández-Lynch MJ, Jancic C, Vermeulen M, Geffner J, Mariuzza RA, Fernández MM, Malchiodi EL. PLoS ONE 8 e66244 (2013)
  9. Understanding TR binding to pMHC complexes: how does a TR scan many pMHC complexes yet preferentially bind to one. Khan JM, Ranganathan S. PLoS ONE 6 e17194 (2011)
  10. Pfit is a structurally novel Crohn's disease-associated superantigen. Liu L, Chen H, Brecher MB, Li Z, Wei B, Nandi B, Zhang J, Ling H, Winslow G, Braun J, Li H. PLoS Pathog. 9 e1003837 (2013)
  11. Crystal structure of the Mycoplasma arthritidis-derived mitogen in apo form reveals a 3D domain-swapped dimer. Liu L, Li Z, Guo Y, VanVranken SJ, Mourad W, Li H. J. Mol. Biol. 399 367-376 (2010)
  12. Superantigen-presentation by rat major histocompatibility complex class II molecules RT1.Bl and RT1.Dl. Dlaske H, Karaüzüm H, Monzon-Casanova E, Rudolf R, Starick L, Müller I, Wildner G, Diedrichs-Möhring M, Koch N, Miyoshi-Akiyama T, Uchiyama T, Wonigeit K, Fleischer B, Overbeck S, Rink L, Herrmann T. Immunology 128 e572-81 (2009)