Structure analysis

Crystal structure of a complete ternary complex between TCR, superantigen, and peptide-MHC class II molecule

X-ray diffraction
2.41Å resolution
Assembly composition:
hetero hexamer (preferred)
Entry contents: 6 distinct polypeptide molecules

Assemblies

Assembly 1 (preferred)
Download    3D Visualisation
Multimeric state: hetero hexamer
Accessible surface area: 36100 Å2
Buried surface area: 13800 Å2
Dissociation area: 1,100 Å2
Dissociation energy (ΔGdiss): -1 kcal/mol
Dissociation entropy (TΔSdiss): 14 kcal/mol
Interface energy (ΔGint): -57 kcal/mol
Symmetry number: 1
Assembly 2
Download    3D Visualisation
Multimeric state: hetero hexamer
Accessible surface area: 36000 Å2
Buried surface area: 13800 Å2
Dissociation area: 1,100 Å2
Dissociation energy (ΔGdiss): -1 kcal/mol
Dissociation entropy (TΔSdiss): 14 kcal/mol
Interface energy (ΔGint): -58 kcal/mol
Symmetry number: 1

Macromolecules

Chains: J, L
Length: 113 amino acids
Theoretical weight: 12.18 KDa
Source organism: Mus musculus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: A2NTY6 (Residues: 30-144; Coverage: 96%)
InterPro:
CATH: Immunoglobulins
SCOP: V set domains (antibody variable domain-like)

Search similar proteins

Chains: I, K
Length: 110 amino acids
Theoretical weight: 12.11 KDa
Source organism: Mus musculus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P01738 (Residues: 21-130; Coverage: 100%)
Pfam: Immunoglobulin V-set domain
InterPro:
CATH: Immunoglobulins

Search similar proteins

Chains: G, H
Length: 213 amino acids
Theoretical weight: 25.33 KDa
Source organism: Mycoplasma arthritidis
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q48898 (Residues: 26-238; Coverage: 90%)
InterPro:
CATH:
SCOP: Superantigen MAM

Search similar proteins