Structure analysis

Structural basis for recognition of mutant self by a tumor-specific, MHC class II-restricted TCR

X-ray diffraction
2.8Å resolution
Source organism: Homo sapiens
Assembly composition:
hetero pentamer (preferred)
Entry contents: 5 distinct polypeptide molecules

Assemblies

Assembly 1 (preferred)
Download    3D Visualisation
Multimeric state: hetero pentamer
Accessible surface area: 35700 Å2
Buried surface area: 14000 Å2
Dissociation area: 1,300 Å2
Dissociation energy (ΔGdiss): -1 kcal/mol
Dissociation entropy (TΔSdiss): 14 kcal/mol
Interface energy (ΔGint): -73 kcal/mol
Symmetry number: 1
Assembly 2
Download    3D Visualisation
Multimeric state: hetero pentamer
Accessible surface area: 36200 Å2
Buried surface area: 14000 Å2
Dissociation area: 1,300 Å2
Dissociation energy (ΔGdiss): -3 kcal/mol
Dissociation entropy (TΔSdiss): 14 kcal/mol
Interface energy (ΔGint): -72 kcal/mol
Symmetry number: 1
Assembly 3
Download    3D Visualisation
Multimeric state: hetero pentamer
Accessible surface area: 36400 Å2
Buried surface area: 14000 Å2
Dissociation area: 1,300 Å2
Dissociation energy (ΔGdiss): -2 kcal/mol
Dissociation entropy (TΔSdiss): 14 kcal/mol
Interface energy (ΔGint): -74 kcal/mol
Symmetry number: 1
Assembly 4
Download    3D Visualisation
Multimeric state: hetero pentamer
Accessible surface area: 36400 Å2
Buried surface area: 14100 Å2
Dissociation area: 1,300 Å2
Dissociation energy (ΔGdiss): -2 kcal/mol
Dissociation entropy (TΔSdiss): 14 kcal/mol
Interface energy (ΔGint): -76 kcal/mol
Symmetry number: 1

Macromolecules

Chains: E, J, O, T
Length: 240 amino acids
Theoretical weight: 27.09 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P01850 (Residues: 1-130; Coverage: 73%)
Gene name: TRBC1
Pfam: Immunoglobulin C1-set domain
InterPro:
CATH: Immunoglobulins

Search similar proteins

Chains: D, I, N, S
Length: 202 amino acids
Theoretical weight: 22.4 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P01848 (Residues: 1-95; Coverage: 67%)
Gene names: TCRA, TRAC
Pfam: Domain of unknown function (DUF1968)
InterPro:
CATH: Immunoglobulins

Search similar proteins

Chains: C, H, M, R
Length: 15 amino acids
Theoretical weight: 1.47 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P60174 (Residues: 60-74; Coverage: 5%)
Gene names: TPI, TPI1

Search similar proteins

Search similar proteins

Search similar proteins