PDBe 2i7q

X-ray diffraction
1.9Å resolution

Crystal structure of Human Choline Kinase A

Released:
Source organism: Homo sapiens
Entry authors: Rabeh WM, Tempel W, Nedyalkova L, Wasney G, Landry R, Arrowsmith CH, Edwards AM, Sundstrom M, Weigelt J, Bochkarev A, Park H, Structural Genomics Consortium (SGC)

Function and Biology Details

Reactions catalysed:
ATP + choline = ADP + phosphocholine. 
ATP + ethanolamine = ADP + O-phosphoethanolamine. 
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Choline kinase alpha Chain: A
Molecule details ›
Chain: A
Length: 402 amino acids
Theoretical weight: 46.99 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P35790 (Residues: 75-457; Coverage: 84%)
Gene names: CHK, CHKA, CKI
Sequence domains: Choline/ethanolamine kinase
Structure domains:

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: P43212
Unit cell:
a: 61.798Å b: 61.798Å c: 218.193Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.231 0.228 0.278
Expression system: Escherichia coli