PDBe 2i6l

X-ray diffraction
2.25Å resolution

Crystal structure of human mitogen activated protein kinase 6 (MAPK6)

Source organism: Homo sapiens
Entry authors: Filippakopoulos P, Turnbull AP, Savitsky P, Fedorov O, Berridge G, Das S, Elkins J, Soundararajan M, Yang XW, Doyle D, Papagrigoriou E, Pike ACW, Bunkonczi G, Ugochukwu E, Debreczeni J, von Delft F, Edwards A, Arrowsmith C, Sundstrom M, Knapp S, Structural Genomics Consortium (SGC)

Function and Biology Details

Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Mitogen-activated protein kinase 6 Chains: A, B
Molecule details ›
Chains: A, B
Length: 320 amino acids
Theoretical weight: 36.28 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
  • Canonical: Q16659 (Residues: 9-327; Coverage: 44%)
Gene names: ERK3, MAPK6, PRKM6
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: P43212
Unit cell:
a: 83.12Å b: 83.12Å c: 181.175Å
α: 90° β: 90° γ: 90°
R R work R free
0.224 0.222 0.272
Expression system: Escherichia coli