PDBe 2i1m

X-ray diffraction
1.8Å resolution

cFMS tyrosine kinase (tie2 KID) in complex with an arylamide inhibitor


Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macrophage colony-stimulating factor 1 receptor Chain: A
Molecule details ›
Chain: A
Length: 333 amino acids
Theoretical weight: 37.61 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
  • Canonical: P07333 (Residues: 538-922; Coverage: 35%)
Gene names: CSF1R, FMS
Structure domains:

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: MACSCIENCE
Spacegroup: R3
Unit cell:
a: 80.44Å b: 80.44Å c: 143.76Å
α: 90° β: 90° γ: 120°
R R work R free
0.25 0.237 0.282
Expression system: Spodoptera frugiperda