PDBe 2i0v

X-ray diffraction
2.8Å resolution

c-FMS tyrosine kinase in complex with a quinolone inhibitor

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Macrophage colony-stimulating factor 1 receptor Chain: A
Molecule details ›
Chain: A
Length: 335 amino acids
Theoretical weight: 38.06 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P07333 (Residues: 538-922; Coverage: 35%)
Gene names: CSF1R, FMS
Structure domains:

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: OTHER
Spacegroup: R3
Unit cell:
a: 82.199Å b: 82.199Å c: 143.3Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.266 0.237 0.296
Expression system: Spodoptera frugiperda