PDBe 2i0e

X-ray diffraction
2.6Å resolution

Structure of catalytic domain of human protein kinase C beta II complexed with a bisindolylmaleimide inhibitor


Function and Biology Details

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Entry contents:
1 distinct polypeptide molecule
Protein kinase C beta type Chains: A, B
Molecule details ›
Chains: A, B
Length: 353 amino acids
Theoretical weight: 40.8 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
  • Canonical: P05771 (Residues: 321-668; Coverage: 52%)
  • Best match: P05771-2 (Residues: 321-673)
Gene names: PKCB, PRKCB, PRKCB1
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

1 bound ligand:

2 modified residues:

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.1
Spacegroup: P21212
Unit cell:
a: 93.098Å b: 131.417Å c: 83.801Å
α: 90° β: 90° γ: 90°
R R work R free
0.237 0.235 0.29
Expression system: Spodoptera frugiperda