PDBe 2hz4

X-ray diffraction
2.8Å resolution

Abl kinase domain unligated and in complex with tetrahydrostaurosporine

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tyrosine-protein kinase ABL1 Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 273 amino acids
Theoretical weight: 31.68 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P00519 (Residues: 228-500; Coverage: 24%)
Gene names: ABL, ABL1, JTK7
Sequence domains: Protein tyrosine kinase
Structure domains:

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06SA
Spacegroup: C2
Unit cell:
a: 185.447Å b: 58.853Å c: 103.977Å
α: 90° β: 119.02° γ: 90°
R-values:
R R work R free
0.22 0.216 0.285
Expression system: Spodoptera frugiperda