PDBe 2hym

Solution NMR

NMR based Docking Model of the Complex between the Human Type I Interferon Receptor and Human Interferon alpha-2

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Interferon alpha/beta receptor 2 Chain: A
Molecule details ›
Chain: A
Length: 212 amino acids
Theoretical weight: 24.32 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P48551 (Residues: 28-237; Coverage: 43%)
  • Best match: P48551-3 (Residues: 28-239)
Gene names: IFNABR, IFNAR2, IFNARB
Sequence domains: Interferon-alpha/beta receptor, fibronectin type III
Structure domains: Immunoglobulins
Interferon alpha-2 Chain: B
Molecule details ›
Chain: B
Length: 165 amino acids
Theoretical weight: 19.26 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P01563 (Residues: 24-188; Coverage: 100%)
Gene names: IFNA2, IFNA2A, IFNA2B, IFNA2C
Sequence domains: Interferon alpha/beta domain
Structure domains: Growth Hormone; Chain: A;

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: Rigid body docking, semi-flexible simulated annealing, refinement using explicit water
Expression system: Escherichia coli