PDBe 2hw6

X-ray diffraction
2.5Å resolution

Crystal structure of Mnk1 catalytic domain

Released:

Function and Biology Details

Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein. 
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
MAP kinase-interacting serine/threonine-protein kinase 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 307 amino acids
Theoretical weight: 34.48 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9BUB5 (Residues: 37-382; Coverage: 66%)
  • Best match: Q9BUB5-2 (Residues: 37-341)
Gene names: MKNK1, MNK1
Structure domains:

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: P43212
Unit cell:
a: 93.468Å b: 93.468Å c: 175.181Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.209 0.207 0.257
Expression system: Escherichia coli