PDBe 2hvc

X-ray diffraction
2.1Å resolution

The Crystal Structure of Ligand-binding Domain (LBD) of human Androgen Receptor in Complex with a selective modulator LGD2226

Released:
Source organism: Homo sapiens
Primary publication:
Structure of the ligand-binding domain (LBD) of human androgen receptor in complex with a selective modulator LGD2226.
Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 62 1067-71 (2006)
PMID: 17077481

Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Androgen receptor Chain: A
Molecule details ›
Chain: A
Length: 250 amino acids
Theoretical weight: 29.15 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P10275 (Residues: 670-919; Coverage: 27%)
Gene names: AR, DHTR, NR3C4
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU
Spacegroup: P212121
Unit cell:
a: 57.64Å b: 65.39Å c: 72.17Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.251 0.221 0.253
Expression system: Escherichia coli BL21(DE3)