PDBe 2hv7

X-ray diffraction
2.5Å resolution

Crystal structure of phosphotyrosyl phosphatase activator bound to ATPgammaS

Released:
Source organism: Homo sapiens

Function and Biology Details

Reaction catalysed:
Peptidylproline (omega=180) = peptidylproline (omega=0). 
Biochemical function:
Cellular component:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Serine/threonine-protein phosphatase 2A activator Chains: A, B, C, D, E, F, G, H
Molecule details ›
Chains: A, B, C, D, E, F, G, H
Length: 323 amino acids
Theoretical weight: 36.82 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q15257 (Residues: 1-358; Coverage: 90%)
  • Best match: Q15257-2 (Residues: 1-323)
Gene names: PPP2R4, PTPA

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X29A
Spacegroup: P1
Unit cell:
a: 80.041Å b: 86.096Å c: 95.099Å
α: 73.91° β: 89.97° γ: 73.31°
R-values:
R R work R free
0.25 0.249 0.312
Expression system: Escherichia coli