› 2hq6

X-ray diffraction
1.75Å resolution

Structure of the Cyclophilin_CeCYP16-Like Domain of the Serologically Defined Colon Cancer Antigen 10 from Homo Sapiens

Released:
DOI: 10.2210/pdb2hq6/pdb
PDB entry 2hq6 coloured by chain, front view.
PDB entry 2hq6 coloured by chain, side view.
PDB entry 2hq6 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural and biochemical characterization of the human cyclophilin family of peptidyl-prolyl isomerases.
Davis TL, Walker JR, Campagna-Slater V, Finerty PJ, Paramanathan R, Bernstein G, MacKenzie F, Tempel W, Ouyang H, Lee WH, Eisenmesser EZ, Dhe-Paganon S
PLoS Biol 8 e1000439 (2010)
PMID: 20676357

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-180424 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Spliceosome-associated protein CWC27 homolog Chain: A
Molecule details ›
Chain: A
Length: 185 amino acids
Theoretical weight: 20.58 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q6UX04 (Residues: 8-173; Coverage: 35%)
Gene names: CWC27, SDCCAG10, UNQ438/PRO871
Sequence domains: Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD
Structure domains: Cyclophilin-like

Ligands and Environments

2 bound ligands:
Ligand IOD 2 x IOD
Ligand GOL 1 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU
Spacegroup: P65
Unit cell:
a: 84.433Å b: 84.433Å c: 55.289Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.167 0.167 0.181
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

36 review citations

Host Factors in Coronavirus Replication.
de Wilde et al. (2018)
35 more

7 mentions without citation

Structural and Functional Insights into Human Nuclear Cyclophilins.
Rajiv et al. (2018)
6 more