PDBe 2hk5

X-ray diffraction
2Å resolution

Hck Kinase in Complex with Lck targetted Inhibitor PG-1009247

Released:

Function and Biology Details

Reaction catalysed:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. 
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tyrosine-protein kinase HCK Chain: A
Molecule details ›
Chain: A
Length: 270 amino acids
Theoretical weight: 30.97 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P08631 (Residues: 247-514; Coverage: 51%)
Gene name: HCK
Sequence domains: Protein tyrosine kinase
Structure domains:

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: P65
Unit cell:
a: 96.977Å b: 96.977Å c: 69.998Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.201 0.198 0.25
Expression system: Escherichia coli