PDBe 2hfp

X-ray diffraction
2Å resolution

Crystal Structure of PPAR Gamma with N-sulfonyl-2-indole carboxamide ligands

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Nuclear receptor coactivator 1 Chain: B
Molecule details ›
Chain: B
Length: 21 amino acids
Theoretical weight: 2.43 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q15788 (Residues: 680-700; Coverage: 2%)
Gene names: BHLHE74, NCOA1, SRC1
Peroxisome proliferator-activated receptor gamma Chain: A
Molecule details ›
Chain: A
Length: 282 amino acids
Theoretical weight: 32.47 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P37231 (Residues: 234-505; Coverage: 54%)
Gene names: NR1C3, PPARG
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: P212121
Unit cell:
a: 46.487Å b: 77.178Å c: 82.075Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.209 0.205 0.285
Expression systems:
  • Not provided
  • Escherichia coli BL21(DE3)