PDBe 2hel

X-ray diffraction
2.35Å resolution

Crystal structure of a mutant EphA4 kinase domain (Y742A)

Released:

Function and Biology Details

Reaction catalysed:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. 
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ephrin type-A receptor 4 Chain: A
Molecule details ›
Chain: A
Length: 306 amino acids
Theoretical weight: 34.58 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: Q03137 (Residues: 591-896; Coverage: 32%)
Gene names: Epha4, Sek, Sek1
Sequence domains: Protein tyrosine kinase
Structure domains:

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU
Spacegroup: P21
Unit cell:
a: 32.283Å b: 101.081Å c: 40.95Å
α: 90° β: 108.8° γ: 90°
R-values:
R R work R free
0.209 0.209 0.248
Expression system: Escherichia coli