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Crystal structure of proteinase K inhibited by a lactoferrin octapeptide Gly-Asp-Glu-Gln-Gly-Glu-Asn-Lys at 2.15 A resolution

X-ray diffraction
2.15Å resolution
PDB entry 2hd4 coloured by chain, front view.
PDB entry 2hd4 coloured by chain, side view.
PDB entry 2hd4 coloured by chain, top view.
Source organisms:
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Proteinase K and Lactotransferrin
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Multimeric state: hetero dimer
Accessible surface area: 10882.22 Å2
Buried surface area: 824.23 Å2
Dissociation area: 365.09 Å2
Dissociation energy (ΔGdiss): -3.94 kcal/mol
Dissociation entropy (TΔSdiss): 6.88 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-136230

Macromolecules

Proteinase K
Chain: A
Length: 279 amino acids
Theoretical weight: 28.96 KDa
Source organism: Parengyodontium album
UniProt:
  • Canonical: P06873 (Residues: 106-384; Coverage: 76%)
Gene name: PROK
Pfam: Subtilase family
InterPro:
CATH: Peptidase S8/S53 domain
SCOP: Subtilases
Proteinase K in PDB entry 2hd4, assembly 1, front view.
Proteinase K in PDB entry 2hd4, assembly 1, side view.
Proteinase K in PDB entry 2hd4, assembly 1, top view.
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Lactotransferrin
Chain: B
Length: 8 amino acids
Theoretical weight: 877 Da
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P02788 (Residues: 528-535; Coverage: 1%)
Gene names: GIG12, LF, LTF
Lactotransferrin in PDB entry 2hd4, assembly 1, front view.
Lactotransferrin in PDB entry 2hd4, assembly 1, side view.
Lactotransferrin in PDB entry 2hd4, assembly 1, top view.
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