2hck Citations

Crystal structure of the Src family tyrosine kinase Hck.

Nature 385 602-9 (1997)
Cited: 564 times
EuropePMC logo PMID: 9024658


The crystal structure of the haematopoietic cell kinase Hck has been determined at 2.6/2.9 A resolution. Inhibition of enzymatic activity is a consequence of intramolecular interactions of the enzyme's Src-homology domains SH2 and SH3, with concomitant displacement of elements of the catalytic domain. The conformation of the active site has similarities with that of inactive cyclin-dependent protein kinases.

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  1. Prospects for circumventing aminoglycoside kinase mediated antibiotic resistance. Shi K, Caldwell SJ, Fong DH, Berghuis AM. Front Cell Infect Microbiol 3 22 (2013)

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