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Crystal structure of human caspase-1 (Glu390->Ala) in complex with 3-[2-(2-benzyloxycarbonylamino-3-methyl-butyrylamino)-propionylamino]-4-oxo-pentanoic acid (z-VAD-FMK)

Source organism: Homo sapiens
Biochemical function: cysteine-type peptidase activity
Biological process: proteolysis
Cellular component: not assigned

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EC 3.4.22.36: Caspase-1

Reaction catalysed:
Strict requirement for an Asp residue at position P1 and has a preferred cleavage sequence of Tyr-Val-Ala-Asp-|-.
Systematic name:
-
Alternative Name(s):
  • ICE
  • Interleukin 1 converting enzyme
  • Interleukin 1-beta converting enzyme
  • Interleukin 1-beta precursor proteinase
  • Interleukin 1-beta-converting endopeptidase
  • Interleukin 1-beta-converting enzyme
  • Interleukin-1 beta convertase precursor
  • Interleukin-1-beta convertase
  • Interleukin-1-beta converting enzyme
  • Interleukin-1-beta precursor proteinase
  • Precursor interleukin-1-beta converting enzyme
  • Pro-interleukin 1-beta proteinase
  • Prointerleukin 1-beta protease
  • Protease A
  • Protease VII

GO terms

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Sequence family

Pfam Protein family (Pfam)
PF00656
Domain description: Caspase domain
Occurring in:
  1. Caspase-1 subunit p20
  2. Caspase-1 subunit p10
The deposited structure of PDB entry 2hby contains 1 copy of Pfam domain PF00656 (Caspase domain) in Caspase-1 subunit p20. Showing 1 copy in chain A.
The deposited structure of PDB entry 2hby contains 1 copy of Pfam domain PF00656 (Caspase domain) in Caspase-1 subunit p10. Showing 1 copy in chain B.

InterPro InterPro annotations
IPR015917
Domain description: Peptidase C14A, caspase catalytic domain
Occurring in:
  1. Caspase-1 subunit p20
  2. Caspase-1 subunit p10
IPR011600
Domain description: Peptidase C14, caspase domain
Occurring in:
  1. Caspase-1 subunit p20
  2. Caspase-1 subunit p10
IPR029030
Domain description: Caspase-like domain superfamily
Occurring in:
  1. Caspase-1 subunit p20
  2. Caspase-1 subunit p10
IPR002398
Domain description: Peptidase C14 family
Occurring in:
  1. Caspase-1 subunit p20
  2. Caspase-1 subunit p10
IPR002138
Domain description: Peptidase C14, caspase non-catalytic subunit p10
Occurring in:
  1. Caspase-1 subunit p10
IPR033139
Domain description: Peptidase family C14A, cysteine active site
Occurring in:
  1. Caspase-1 subunit p20
IPR016129
Domain description: Peptidase family C14A, His active site
Occurring in:
  1. Caspase-1 subunit p20
IPR001309
Domain description: Peptidase C14, p20 domain
Occurring in:
  1. Caspase-1 subunit p20

Structure domains

CATH CATH domains
3.30.70.1470
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Alpha-Beta Plaits
Homology: Caspase-like
Occurring in:
  1. Caspase-1 subunit p10
The deposited structure of PDB entry 2hby contains 1 copy of CATH domain 3.30.70.1470 (Alpha-Beta Plaits) in Caspase-1 subunit p10. Showing 1 copy in chain B.
3.40.50.1460
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: Rossmann fold
Occurring in:
  1. Caspase-1 subunit p20
The deposited structure of PDB entry 2hby contains 1 copy of CATH domain 3.40.50.1460 (Rossmann fold) in Caspase-1 subunit p20. Showing 1 copy in chain A.

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