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STRUCTURE OF A HAP1-18/DNA COMPLEX REVEALS THAT PROTEIN/DNA INTERACTIONS CAN HAVE DIRECT ALLOSTERIC EFFECTS ON TRANSCRIPTIONAL ACTIVATION

Source organism: Saccharomyces cerevisiae
Biochemical function: zinc ion binding
Biological process: regulation of DNA-templated transcription
Cellular component: not assigned

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GO terms

Sequence family

Pfam Protein family (Pfam)
PF00172
Domain description: Fungal Zn(2)-Cys(6) binuclear cluster domain
Occurring in:
  1. Heme-responsive zinc finger transcription factor HAP1
The deposited structure of PDB entry 2hap contains 2 copies of Pfam domain PF00172 (Fungal Zn(2)-Cys(6) binuclear cluster domain) in Heme-responsive zinc finger transcription factor HAP1. Showing 1 copy in chain C.

InterPro InterPro annotations
IPR001138
Domain description: Zn(2)Cys(6) fungal-type DNA-binding domain
Occurring in:
  1. Heme-responsive zinc finger transcription factor HAP1
IPR036864
Domain description: Zn(2)-C6 fungal-type DNA-binding domain superfamily
Occurring in:
  1. Heme-responsive zinc finger transcription factor HAP1
IPR046347
Domain description: Basic-leucine zipper domain superfamily
Occurring in:
  1. Heme-responsive zinc finger transcription factor HAP1

Structure domains

CATH CATH domains
1.20.5.170
Class: Mainly Alpha
Architecture: Up-down Bundle
Topology: Single alpha-helices involved in coiled-coils or other helix-helix interfaces
Homology: Single alpha-helices involved in coiled-coils or other helix-helix interfaces
Occurring in:
  1. Heme-responsive zinc finger transcription factor HAP1
The deposited structure of PDB entry 2hap contains 2 copies of CATH domain 1.20.5.170 (Single alpha-helices involved in coiled-coils or other helix-helix interfaces) in Heme-responsive zinc finger transcription factor HAP1. Showing 1 copy in chain C.
4.10.240.10
Class: Few Secondary Structures
Architecture: Irregular
Topology: CD2-Gal4
Homology: Zn(2)-C6 fungal-type DNA-binding domain
Occurring in:
  1. Heme-responsive zinc finger transcription factor HAP1
The deposited structure of PDB entry 2hap contains 2 copies of CATH domain 4.10.240.10 (CD2-Gal4) in Heme-responsive zinc finger transcription factor HAP1. Showing 1 copy in chain C.
SCOP SCOP annotations
57960
Class: Coiled coil proteins
Fold: Parallel coiled-coil
Superfamily: Leucine zipper domain
Occurring in:
  1. Heme-responsive zinc finger transcription factor HAP1
The deposited structure of PDB entry 2hap contains 2 copies of SCOP domain 57960 (Leucine zipper domain) in Heme-responsive zinc finger transcription factor HAP1. Showing 1 copy in chain C.
57702
Class: Small proteins
Fold: Zn2/Cys6 DNA-binding domain
Superfamily: Zn2/Cys6 DNA-binding domain
Occurring in:
  1. Heme-responsive zinc finger transcription factor HAP1
The deposited structure of PDB entry 2hap contains 2 copies of SCOP domain 57702 (Zn2/Cys6 DNA-binding domain) in Heme-responsive zinc finger transcription factor HAP1. Showing 1 copy in chain C.

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