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Histone H3 recognition and presentation by the WDR5 module of the MLL1 complex

X-ray diffraction
1.79Å resolution
PDB entry 2h68 coloured by chain, front view.
PDB entry 2h68 coloured by chain, side view.
PDB entry 2h68 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: WD repeat-containing protein 5
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Multimeric state: monomeric
Accessible surface area: 11903.88 Å2
Buried surface area: 0.0 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-158474
Assembly 2
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Assembly Name: WD repeat-containing protein 5
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Multimeric state: monomeric
Accessible surface area: 12101.49 Å2
Buried surface area: 0.0 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-158474

Macromolecules

WD repeat-containing protein 5
Chains: A, B
Length: 312 amino acids
Theoretical weight: 34.3 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P61964 (Residues: 23-334; Coverage: 93%)
Gene names: BIG3, WDR5
Pfam: WD domain, G-beta repeat
InterPro:
CATH: YVTN repeat-like/Quinoprotein amine dehydrogenase
WD repeat-containing protein 5 in PDB entry 2h68, assembly 1, front view.
WD repeat-containing protein 5 in PDB entry 2h68, assembly 1, side view.
WD repeat-containing protein 5 in PDB entry 2h68, assembly 1, top view.
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