› 2h4v

X-ray diffraction
1.55Å resolution

Crystal Structure of the Human Tyrosine Receptor Phosphatase Gamma

Released:
DOI: 10.2210/pdb2h4v/pdb
PDB entry 2h4v coloured by chain, front view.
PDB entry 2h4v coloured by chain, side view.
PDB entry 2h4v coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Large-scale structural analysis of the classical human protein tyrosine phosphatome.
Barr AJ, Ugochukwu E, Lee WH, King ON, Filippakopoulos P, Alfano I, Savitsky P, Burgess-Brown NA, Müller S, Knapp S
Cell 136 352-63 (2009)
PMID: 19167335

Function and Biology Details

Reaction catalysed: 
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-149980 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Receptor-type tyrosine-protein phosphatase gamma Chains: A, B
Molecule details ›
Chains: A, B
Length: 320 amino acids
Theoretical weight: 37.11 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P23470 (Residues: 831-1127; Coverage: 21%)
Gene names: PTPG, PTPRG
Sequence domains: Protein-tyrosine phosphatase
Structure domains: Protein tyrosine phosphatase superfamily

Ligands and Environments

5 bound ligands:
Ligand CL 7 x CL
Ligand FLC 1 x FLC
Ligand ACT 2 x ACT
Ligand EDO 5 x EDO
Ligand NA 1 x NA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: P212121
Unit cell:
a: 74.849Å b: 78.859Å c: 121.758Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.162 0.161 0.181
Expression system: Escherichia coli

Quick links

Citations

58 review citations

Inside the human cancer tyrosine phosphatome.
Julien et al. (2011)
57 more

2 mentions without citation

Protein tyrosine phosphatases: structure, function, and implication in human disease.
Tautz et al. (2013)
1 more