PDBe 2h46

X-ray diffraction
1.9Å resolution

Native domain-swapped dimer crystal structure of the Grb2 SH2 domain

Released:
Source organism: Homo sapiens
Primary publication:
Structural and energetic aspects of Grb2-SH2 domain-swapping.
Arch. Biochem. Biophys. 462 47-53 (2007)
PMID: 17466257

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assemblies composition:
homo dimer (preferred)
homo octamer
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Growth factor receptor-bound protein 2 Chain: E
Molecule details ›
Chain: E
Length: 116 amino acids
Theoretical weight: 13.69 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P62993 (Residues: 53-162; Coverage: 51%)
Gene names: ASH, GRB2
Sequence domains: SH2 domain
Structure domains: SHC Adaptor Protein

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU200
Spacegroup: I422
Unit cell:
a: 80.783Å b: 80.783Å c: 75.216Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.22 0.222 0.231
Expression system: Escherichia coli