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Crystal structure of murine carnitine acetyltransferase in complex with carnitine and acetyl-CoA

X-ray diffraction
2.2Å resolution
PDB entry 2h3p coloured by chain, front view.
PDB entry 2h3p coloured by chain, side view.
PDB entry 2h3p coloured by chain, top view.
Source organism: Mus musculus
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1
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Assembly Name: Carnitine O-acetyltransferase
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Multimeric state: monomeric
Accessible surface area: 24353.3 Å2
Buried surface area: 1661.75 Å2
Dissociation area: 622.22 Å2
Dissociation energy (ΔGdiss): -5.21 kcal/mol
Dissociation entropy (TΔSdiss): 6.68 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-155681
Assembly 2 (preferred)
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Assembly Name: Carnitine O-acetyltransferase
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Multimeric state: monomeric
Accessible surface area: 24536.22 Å2
Buried surface area: 1746.99 Å2
Dissociation area: 255.89 Å2
Dissociation energy (ΔGdiss): -1.57 kcal/mol
Dissociation entropy (TΔSdiss): 2.36 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-155681

Macromolecules

Carnitine O-acetyltransferase
Chains: A, B
Length: 599 amino acids
Theoretical weight: 68.04 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: P47934 (Residues: 30-625; Coverage: 95%)
Gene name: Crat
Pfam: Choline/Carnitine o-acyltransferase
InterPro:
CATH:
SCOP: Choline/Carnitine O-acyltransferase
Carnitine O-acetyltransferase in PDB entry 2h3p, assembly 2, front view.
Carnitine O-acetyltransferase in PDB entry 2h3p, assembly 2, side view.
Carnitine O-acetyltransferase in PDB entry 2h3p, assembly 2, top view.
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