PDBe 2h02

X-ray diffraction
2.3Å resolution

Structural studies of protein tyrosine phosphatase beta catalytic domain in complex with inhibitors

Released:

Function and Biology Details

Reaction catalysed:
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate. 
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Receptor-type tyrosine-protein phosphatase beta Chains: A, B
Molecule details ›
Chains: A, B
Length: 313 amino acids
Theoretical weight: 36.29 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P23467 (Residues: 1662-1973; Coverage: 16%)
Gene names: PTPB, PTPRB
Sequence domains: Protein-tyrosine phosphatase
Structure domains: Protein tyrosine phosphatase superfamily

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: P21
Unit cell:
a: 62.144Å b: 71.724Å c: 70.297Å
α: 90° β: 93.41° γ: 90°
R-values:
R R work R free
0.192 0.189 0.244
Expression system: Escherichia coli