PDBe 2gy7

X-ray diffraction
3.7Å resolution

Angiopoietin-2/Tie2 Complex Crystal Structure

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Angiopoietin-2 Chain: A
Molecule details ›
Chain: A
Length: 216 amino acids
Theoretical weight: 24.75 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: O15123 (Residues: 281-495; Coverage: 45%)
Gene name: ANGPT2
Structure domains:
Angiopoietin-1 receptor Chain: B
Molecule details ›
Chain: B
Length: 423 amino acids
Theoretical weight: 47.19 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q02763 (Residues: 23-445; Coverage: 38%)
Gene names: TEK, TIE2, VMCM, VMCM1
Sequence domains: Tie-2 Ig-like domain 1
Structure domains:

Ligands and Environments


No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X29A
Spacegroup: P41212
Unit cell:
a: 165.636Å b: 165.636Å c: 115.31Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.24 0.24 0.317
Expression system: Not provided