PDBe 2gtm

X-ray diffraction
1.9Å resolution

Mutated Mouse P38 MAP Kinase Domain in complex with Inhibitor PG-892579

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Mitogen-activated protein kinase 14 Chain: A
Molecule details ›
Chain: A
Length: 348 amino acids
Theoretical weight: 39.9 KDa
Source organism: Mus musculus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P47811 (Residues: 5-352; Coverage: 97%)
Gene names: Crk1, Csbp1, Csbp2, Mapk14
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: P212121
Unit cell:
a: 63.876Å b: 73.627Å c: 76.16Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.231 0.212 0.261
Expression system: Escherichia coli BL21(DE3)