› 2gry

X-ray diffraction
2.35Å resolution

Crystal structure of the human KIF2 motor domain in complex with ADP

Released:
DOI: 10.2210/pdb2gry/pdb
PDB entry 2gry coloured by chain, front view.
PDB entry 2gry coloured by chain, side view.
PDB entry 2gry coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Wang J, Shen Y, Tempel W, Landry R, Arrowsmith CH, Edwards AM, Sundstrom M, Weigelt J, Bochkarev A, Park H, Structural Genomics Consortium (SGC)

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-126118 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Kinesin-like protein KIF2A Chain: A
Molecule details ›
Chain: A
Length: 420 amino acids
Theoretical weight: 47.92 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O00139 (Residues: 153-553; Coverage: 57%)
Gene names: KIF2, KIF2A, KNS2
Sequence domains: Kinesin motor domain
Structure domains: Kinesin motor domain

Ligands and Environments

3 bound ligands:
Ligand MG 1 x MG
Ligand ADP 1 x ADP
Ligand UNX 3 x UNX
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU FR-E
Spacegroup: R32
Unit cell:
a: 121.475Å b: 121.475Å c: 175.684Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.224 0.222 0.283
Expression system: Escherichia coli

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