PDBe 2gpv

X-ray diffraction
2.85Å resolution

Estrogen Related Receptor-gamma ligand binding domain complexed with 4-hydroxy-tamoxifen and a SMRT peptide


Function and Biology Details

Structure analysis Details

Assemblies composition:
hetero nonamer (preferred)
hetero 18-mer
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Chromosome undetermined SCAF24640, whole genome shotgun sequence Chains: G, H, I
Molecule details ›
Chains: G, H, I
Length: 22 amino acids
Theoretical weight: 2.6 KDa
Source organism: Tetraodon nigroviridis
Expression system: Not provided
  • Canonical: Q4RA23 (Residues: 135-156; Coverage: 13%)
Gene name: GSTENG00037368001
Estrogen-related receptor gamma Chains: A, B, C, D, E, F
Molecule details ›
Chains: A, B, C, D, E, F
Length: 230 amino acids
Theoretical weight: 26.08 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
  • Canonical: P62508 (Residues: 229-458; Coverage: 50%)
Gene names: ERR3, ERRG2, ESRRG, KIAA0832, NR3B3
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 17-ID
Spacegroup: C2
Unit cell:
a: 200.22Å b: 117.17Å c: 90.47Å
α: 90° β: 102.36° γ: 90°
R R work R free
0.221 0.219 0.279
Expression systems:
  • Not provided
  • Escherichia coli BL21(DE3)