PDBe 2gpp

X-ray diffraction
2.6Å resolution

Estrogen Related Receptor-gamma ligand binding domain complexed with a RIP140 peptide and synthetic ligand GSK4716

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Estrogen-related receptor gamma Chains: A, B
Molecule details ›
Chains: A, B
Length: 230 amino acids
Theoretical weight: 26.08 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P62508 (Residues: 229-458; Coverage: 50%)
Gene names: ERR3, ERRG2, ESRRG, KIAA0832, NR3B3
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor
Nuclear receptor-interacting protein 1 Chains: C, D
Molecule details ›
Chains: C, D
Length: 25 amino acids
Theoretical weight: 2.83 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P48552 (Residues: 366-390; Coverage: 2%)
Gene name: NRIP1

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 17-ID
Spacegroup: R3
Unit cell:
a: 203.81Å b: 203.81Å c: 53.46Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.233 0.232 0.257
Expression systems:
  • Escherichia coli BL21(DE3)
  • Not provided