PDBe 2gph

X-ray diffraction
1.9Å resolution

Docking motif interactions in the MAP kinase ERK2

Released:

Function and Biology Details

Reactions catalysed:
ATP + a protein = ADP + a phosphoprotein. 
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate. 
Biochemical function:
Cellular component:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Mitogen-activated protein kinase 1 Chain: A
Molecule details ›
Chain: A
Length: 364 amino acids
Theoretical weight: 42.16 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli
UniProt:
  • Canonical: P63086 (Residues: 2-358; Coverage: 100%)
Gene names: Erk2, Mapk, Mapk1, Prkm1
Sequence domains: Protein kinase domain
Structure domains:
Tyrosine-protein phosphatase non-receptor type 7 Chain: B
Molecule details ›
Chain: B
Length: 16 amino acids
Theoretical weight: 1.86 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P35236 (Residues: 37-52; Coverage: 4%)
Gene name: PTPN7

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-BM
Spacegroup: P212121
Unit cell:
a: 45.981Å b: 66.342Å c: 116.112Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.231 0.216 0.263
Expression systems:
  • Escherichia coli
  • Not provided