PDBe 2goo

X-ray diffraction
2.2Å resolution

Ternary Complex of BMP-2 bound to BMPR-Ia-ECD and ActRII-ECD

Released:
Source organisms:
Primary publication:
Structure of the ternary signaling complex of a TGF-beta superfamily member.
Proc. Natl. Acad. Sci. U.S.A. 103 7643-8 (2006)
PMID: 16672363

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero hexamer (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Activin receptor type-2A Chains: C, F
Molecule details ›
Chains: C, F
Length: 102 amino acids
Theoretical weight: 12.02 KDa
Source organism: Mus musculus
Expression system: Komagataella pastoris
UniProt:
  • Canonical: P27038 (Residues: 20-121; Coverage: 21%)
Gene names: Acvr2, Acvr2a
Sequence domains: Activin types I and II receptor domain
Structure domains: CD59
Bone morphogenetic protein 2 Chains: A, D
Molecule details ›
Chains: A, D
Length: 114 amino acids
Theoretical weight: 12.92 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P12643 (Residues: 283-396; Coverage: 31%)
Gene names: BMP2, BMP2A
Sequence domains: Transforming growth factor beta like domain
Structure domains: Cystine-knot cytokines
Bone morphogenetic protein receptor type-1A Chains: B, E
Molecule details ›
Chains: B, E
Length: 131 amino acids
Theoretical weight: 14.34 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P36894 (Residues: 24-152; Coverage: 25%)
Gene names: ACVRLK3, ALK3, BMPR1A
Sequence domains: Activin types I and II receptor domain
Structure domains: CD59

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.1
Spacegroup: P6522
Unit cell:
a: 104.031Å b: 104.031Å c: 362.526Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.224 0.222 0.259
Expression systems:
  • Komagataella pastoris
  • Escherichia coli