PDBe 2gl7

X-ray diffraction
2.6Å resolution

Crystal Structure of a beta-catenin/BCL9/Tcf4 complex

Released:
Source organism: Homo sapiens
Primary publication:
Crystal structure of a beta-catenin/BCL9/Tcf4 complex.
Mol. Cell 24 293-300 (2006)
PMID: 17052462

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Catenin beta-1 Chains: A, D
Molecule details ›
Chains: A, D
Length: 550 amino acids
Theoretical weight: 60.24 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P35222 (Residues: 138-686; Coverage: 70%)
  • Best match: P35222-2 (Residues: 1-82, 83-86)
Gene names: CTNNB, CTNNB1, OK/SW-cl.35, PRO2286
Sequence domains: Armadillo/beta-catenin-like repeat
Structure domains: Leucine-rich Repeat Variant
B-cell CLL/lymphoma 9 protein Chains: C, F
Molecule details ›
Chains: C, F
Length: 46 amino acids
Theoretical weight: 5.29 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O00512 (Residues: 347-392; Coverage: 3%)
Gene name: BCL9
Sequence domains: B-cell lymphoma 9 protein
Transcription factor 7-like 2 Chains: B, E
Molecule details ›
Chains: B, E
Length: 53 amino acids
Theoretical weight: 5.63 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9NQB0 (Residues: 1-53; Coverage: 9%)
Gene names: TCF4, TCF7L2

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.1
Spacegroup: P21212
Unit cell:
a: 96.764Å b: 119.441Å c: 130.549Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.223 0.221 0.267
Expression system: Escherichia coli