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The complex between TCR A6 and human Class I MHC HLA-A2 with the modified HTLV-1 TAX (Y5K-4-[3-Indolyl]-butyric acid) peptide

X-ray diffraction
2.56Å resolution
PDB entry 2gj6 coloured by chain, front view.
PDB entry 2gj6 coloured by chain, side view.
PDB entry 2gj6 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero pentamer (preferred)
Entry contents: 5 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero pentamer
Accessible surface area: 37765.33 Å2
Buried surface area: 15031.8 Å2
Dissociation area: 1,481.96 Å2
Dissociation energy (ΔGdiss): 11.57 kcal/mol
Dissociation entropy (TΔSdiss): 8.11 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-134730

Macromolecules

HLA class I histocompatibility antigen, A alpha chain
Chain: A
Length: 275 amino acids
Theoretical weight: 31.85 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P04439 (Residues: 25-299; Coverage: 81%)
Gene names: HLA-A, HLAA
Pfam:
InterPro:
CATH:
SCOP:
HLA class I histocompatibility antigen, A alpha chain in PDB entry 2gj6, assembly 1, front view.
HLA class I histocompatibility antigen, A alpha chain in PDB entry 2gj6, assembly 1, side view.
HLA class I histocompatibility antigen, A alpha chain in PDB entry 2gj6, assembly 1, top view.
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Beta-2-microglobulin
Chain: B
Length: 100 amino acids
Theoretical weight: 11.88 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P61769 (Residues: 21-119; Coverage: 100%)
Gene names: B2M, CDABP0092, HDCMA22P
Pfam: Immunoglobulin C1-set domain
InterPro:
CATH: Immunoglobulins
SCOP: C1 set domains (antibody constant domain-like)
Beta-2-microglobulin in PDB entry 2gj6, assembly 1, front view.
Beta-2-microglobulin in PDB entry 2gj6, assembly 1, side view.
Beta-2-microglobulin in PDB entry 2gj6, assembly 1, top view.
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Modified HTLV-1 TAX (Y5K-IBA) peptide, chain C
Chain: C
Length: 9 amino acids
Theoretical weight: 1.04 KDa
Modified HTLV-1 TAX (Y5K-IBA) peptide, chain C in PDB entry 2gj6, assembly 1, front view.
Modified HTLV-1 TAX (Y5K-IBA) peptide, chain C in PDB entry 2gj6, assembly 1, side view.
Modified HTLV-1 TAX (Y5K-IBA) peptide, chain C in PDB entry 2gj6, assembly 1, top view.
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T cell receptor alpha chain constant
Chain: D
Length: 200 amino acids
Theoretical weight: 22.09 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P01848 (Residues: 1-89; Coverage: 64%)
Gene names: TCRA, TRAC
Pfam: Domain of unknown function (DUF1968)
InterPro:
CATH: Immunoglobulins
SCOP:
T cell receptor alpha chain constant in PDB entry 2gj6, assembly 1, front view.
T cell receptor alpha chain constant in PDB entry 2gj6, assembly 1, side view.
T cell receptor alpha chain constant in PDB entry 2gj6, assembly 1, top view.
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T cell receptor beta constant 1
Chain: E
Length: 245 amino acids
Theoretical weight: 27.36 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P01850 (Residues: 1-129; Coverage: 73%)
Gene name: TRBC1
Pfam: Immunoglobulin C1-set domain
InterPro:
CATH: Immunoglobulins
SCOP:
T cell receptor beta constant 1 in PDB entry 2gj6, assembly 1, front view.
T cell receptor beta constant 1 in PDB entry 2gj6, assembly 1, side view.
T cell receptor beta constant 1 in PDB entry 2gj6, assembly 1, top view.
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