Function and Biology

CTD-specific phosphatase Scp1 in complex with peptide C-terminal domain of RNA polymerase II

Source organism: Homo sapiens
Biochemical function: phosphatase activity
Biological process: not assigned
Cellular component: not assigned

EC 2.7.7.6: DNA-directed RNA polymerase

Reaction catalysed:
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1)
Systematic name:
Nucleoside-triphosphate:RNA nucleotidyltransferase (DNA-directed)
Alternative Name(s):
  • C RNA formation factors
  • C ribonucleic acid formation factors
  • DNA-dependent RNA nucleotidyltransferase
  • DNA-dependent RNA polymerase
  • DNA-dependent ribonucleate nucleotidyltransferase
  • Deoxyribonucleic acid-dependent ribonucleic acid polymerase
  • RNA nucleotidyltransferase
  • RNA nucleotidyltransferase (DNA-directed)
  • RNA polymerase
  • RNA polymerase I
  • RNA polymerase II
  • RNA polymerase III
  • RNA transcriptase
  • Ribonucleate nucleotidyltransferase
  • Ribonucleate polymerase
  • Ribonucleic acid nucleotidyltransferase
  • Ribonucleic acid polymerase
  • Ribonucleic acid transcriptase
  • Ribonucleic polymerase
  • Ribonucleic transcriptase
  • Transcriptase

EC 2.7.7.48: RNA-directed RNA polymerase

Reaction catalysed:
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1)
Systematic name:
Nucleoside-triphosphate:RNA nucleotidyltransferase (RNA-directed)
Alternative Name(s):
  • 3D polymerase
  • PB1 proteins
  • PB2 proteins
  • Phage f2 replicase
  • Polymerase L
  • Q-beta replicase
  • RDRP
  • RNA nucleotidyltransferase (RNA-directed)
  • RNA replicase
  • RNA synthetase
  • RNA transcriptase
  • RNA-dependent RNA polymerase
  • RNA-dependent RNA replicase
  • RNA-dependent ribonucleate nucleotidyltransferase
  • Ribonucleic acid replicase
  • Ribonucleic acid-dependent ribonucleate nucleotidyltransferase
  • Ribonucleic acid-dependent ribonucleic acid polymerase
  • Ribonucleic replicase
  • Ribonucleic synthetase
  • Transcriptase

EC 3.1.3.16: Protein-serine/threonine phosphatase

Reaction catalysed:
[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate
Systematic name:
Phosphoprotein phosphohydrolase
Alternative Name(s):
  • 3-hydroxy 3-methylglutaryl coenzymeA reductase phosphatase
  • Aspergillus awamori acid protein phosphatase
  • BCKDH phosphatase
  • Branched-chain alpha-keto acid dehydrogenase phosphatase
  • Calcineurin
  • Casein phosphatase
  • HMG-CoA reductase phosphatase
  • Phosphatase 2A
  • Phosphatase 2B
  • Phosphatase C-II
  • Phosphatase H-II
  • Phosphatase I
  • Phosphatase IB
  • Phosphatase II
  • Phosphatase III
  • Phosphatase IV
  • Phosphatase SP
  • Phosphoprotein phosphatase
  • Phosphopyruvate dehydrogenase phosphatase
  • Phosphospectrin phosphatase
  • Polycation modulated (PCM-) phosphatase
  • Protein D phosphatase
  • Protein phosphatase
  • Protein phosphatase-1
  • Protein phosphatase-2A
  • Protein phosphatase-2B
  • Protein phosphatase-2C
  • Serine/threonine specific protein phosphatase

GO terms

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned

Sequence families

Pfam Protein families (Pfam)
PF05001
Domain description: RNA polymerase Rpb1 C-terminal repeat
Occurring in:
  1. DNA-directed RNA polymerase II subunit RPB1
The deposited structure of PDB entry 2ghq contains 4 copies of Pfam domain PF05001 (RNA polymerase Rpb1 C-terminal repeat) in DNA-directed RNA polymerase II subunit RPB1. Showing 2 copies in chain D.

PF03031
Domain description: NLI interacting factor-like phosphatase
Occurring in:
  1. Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1
The deposited structure of PDB entry 2ghq contains 2 copies of Pfam domain PF03031 (NLI interacting factor-like phosphatase) in Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR004274
Domain description: FCP1 homology domain
Occurring in:
  1. Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1
IPR011948
Domain description: Dullard phosphatase domain, eukaryotic
Occurring in:
  1. Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1
IPR036412
Domain description: HAD-like superfamily
Occurring in:
  1. Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1
IPR023214
Domain description: HAD superfamily
Occurring in:
  1. Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1

Structure domain

CATH CATH domain
3.40.50.1000
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: HAD superfamily/HAD-like
Occurring in:
  1. Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1
The deposited structure of PDB entry 2ghq contains 2 copies of CATH domain 3.40.50.1000 (Rossmann fold) in Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1. Showing 1 copy in chain A.