PDBe 2gcd

X-ray diffraction
2.55Å resolution

TAO2 kinase domain-staurosporine structure

Released:
Source organism: Rattus norvegicus
Primary publication:
Crystal structure of the MAP3K TAO2 kinase domain bound by an inhibitor staurosporine.
Acta Biochim. Biophys. Sin. (Shanghai) 38 385-92 (2006)
PMID: 16761096

Function and Biology Details

Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein. 
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Serine/threonine-protein kinase TAO2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 309 amino acids
Theoretical weight: 35.44 KDa
Source organism: Rattus norvegicus
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q9JLS3 (Residues: 12-320; Coverage: 25%)
Gene names: Tao2, Taok2
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

1 bound ligand:

1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU300
Spacegroup: P6522
Unit cell:
a: 186.019Å b: 186.019Å c: 94.641Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.203 0.199 0.261
Expression system: Spodoptera frugiperda